The Elric brothers’ long Fullmetal Alchemist: Final Transmutation and winding journey comes to a close in this epic finale, where they must face off against an unworldly, nationwide threat.
In the country of Amestris, Edward Elric and his younger brother Alphonse live in the rural town of Resembool with their mother Trisha while self-learning alchemy at a young age. When the brothers commit the taboo act of Human Transmutation to resurrect Trisha after she dies of illness, it backfires and they face the consequences via the Law of Equivalent Exchange: Edward loses his left leg, while Alphonse is dragged into the Gate of Truth. Edward then sacrifices his Fullmetal Alchemist: Final Transmutation right arm to save his brother’s soul and bind it to a suit of armor via a blood seal, later replacing his missing limbs with “automail” prosthetics. Edward later receives an invitation by Colonel Roy Mustang to join the military so he can research a means of restoring Alphonse’s body. After becoming a State Alchemist with the title “Fullmetal Alchemist”, accompanied by their childhood friend and Automail mechanic Winry Rockbell, Edward begins his quest with Alphonse to find the legendary philosopher’s stone which could repair their bodies.
Years later, Edward and Alphonse confront a cultist named Father Cornello, whom they believe is using a philosopher’s stone to recruit the people of Liore. As Mustang arrives to personally handle the situation, Edward exposes Cornello while the stone is revealed to be a fake. After reaching East City and spending the night at the home of Major Maes Hughes and his pregnant wife, the brothers are provided with lodging when Major General Hakuro introduces them to Shou Tucker, a bio-alchemy authority who obtained his State Alchemist credentials by creating a talking chimera. As the brothers become fast friends with the man’s young daughter Nina and their dog Alexander, Tucker suggests Edward to find Dr. Tim Marcoh as he created a philosopher’s stone prior to going into hiding. Alphonse remains behind to be examined by Tucker, who causes Alphonse to question his existence, while Edward and Winry head to Marcoh’s last known whereabouts.
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